GPAT- 2012

GPAT - Graduate Pharmacy Aptitude Test is Maharaja Sayajirao University of Baroda, Vadodara under the aegis of National Monitoring Committee, All India Council for Technical Education (AICTE), New Delhi for for admission in Master’s programme in Pharmacy (M.Pharma) and also for awarding fellowships/scholarships to Pharmacy graduate along with engineering graduates.

GPAT 2012 Structure:-

GPAT-2012 Examination will be paper-pencil examination. It will consist of a single paper of 3 hours duration containing 150 questions, each of three (03) marks. The question paper will consist of multiple choice objective questions only. Each question will have four choices for the answer. The candidates will have to mark the correct choice on an Optical Response Sheet (ORS) by darkening the appropriate bubble against each question. Three (03) marks will be awarded for each right answer and zero (00) marks for no attempts. One (01) mark will be deducted for each wrong answer.

GPAT Syllabus 2012:-

Pharmaceutics:-

* Introduction to Physical pharmacy; Matter, Properties of Matter
* Micromeretics and Powder Rheology
* Surface and Interfacial Phenomenon
* Viscosity and Rheology
* Dispersion Systems
* Complexation
* Importance of microbiology in pharmacy; Structure of bacterial cell; Classification of microbes and their taxonomy
* Identification of Microbes
* Control of microbes by physical and chemical methods
* Sterilization
* Immunology and Immunological Preparations
* Genetic Recombination
* Antibiotics
* Introduction to pharmaceutical jurisprudence & ethics
* Pharmaceutical Ethics; Pharmacy Act 1948
* Introduction to dispensing and community pharmacy; Prescription
* Principles involved and procedures adopted in dispensing
* Incompatibilities
* Community Pharmacy Organization and Structure of hospital pharmacy
* Hospital Formulary
* Drug Store Management and Inventory Control
* Drug distribution Systems in Hospitals
* Central Sterile Supply Unit and their Management
* Manufacture of Sterile and Non-sterile Products
* Drug Information Services
* Records and Reports
* Nuclear Pharmacy
* Importance of unit operations in manufacturing; Stoichiometry
* Fluid Flow
* Heat transfer
* Evaporation
* Distillation
* Drying
* Size Reduction
* Mixing
* Crystallization
* Dehumidification and Humidity Control
* Refrigeration and Air Conditioning
* Material of Construction
* Material Handling Systems
* Corrosion
* Plant location
* Industrial Hazards and Safety Precautions
* Automated Process Control Systems
* Liquid Dosages Forms
* Semisolid Dosage Forms
* Suppositories
* Extraction and Galenical Products
* Blood Products and Plasma Substitutes
* Pharmaceutical Aerosols
* Ophthalmic Preparations
* Cosmeticology and Cosmetic Preparations
* Capsules

Micro-encapsulation
* Tablets
* Parenteral Products
* Surgical products
* Packaging of Pharmaceutical Products
* Designing of dosage forms; Pre-formulation studies
* Performance evaluation methods
* Biopharmaceutics
* Pharmacokinetics
* Clinical Pharmacokinetics
* Bioavailability and bioequivalence

Pharmaceutical Chemistry:-

* Importance of inorganic compounds in pharmacy and medicine
* Gastrointestinal Agents
* Essential and Trace Elements
* Topical Agents
* Gases and Vapors
* Dental Products
* Miscellaneous Agents
* Pharmaceutical Aids Used in Pharmaceutical Industry
* Acids, Bases and Buffers
* Inorganic Radiopharmaceuticals
* Importance of basic fundamentals of physical chemistry in pharmacy; Behaviour of Gases
* Kinetic theory of gases, deviation from ideal behavior and explanation
* Solutions
* Thermodynamics
* Thermochemical equations; Phase rule; Adsorption
* Photochemistry
* Chemical Kinetics
* Quantum Mechanics
* Importance of fundamentals of organic chemistry in pharmaceutical sciences; Structure and Properties
* Stereochemistry

Stereoselective and stereospecific reactions; Structure, Nomenclature, Preparation and Reactions of
* Nucleophilic and Electrophilic Aromatic Substitution Reactions
* Electrophilic and Nucleophilic Addition Reactions
* Elimination reactions; Conservation of Orbital Symmetry and Rules
* Neighboring group effects; Catalysis by transition metal complexes; Heterocyclic Compounds
* Biochemistry in pharmaceutical sciences; The concept of free energy
* Enzymes
* Co-enzymes
* The Citric Acid Cycle
* Lipids Metabolism
* Biological Oxidation
* Metabolism of ammonia and nitrogen containing monomers
* Purine biosynthesis
* Pyrimidine biosynthesis
* Biosynthesis of Nucleic Acids
* Mutation
* Genetic Code and Protein Synthesis
* Basic Principles of Medicinal Chemistry
* Drug metabolism and Concept of Prodrugs; Principles of Drug Design (Theoretical Aspects)
* Synthetic Procedures, Mode of Action, Uses, Structure Activity Relationships including Physicochemical Properties of the Following Classes of Drugs
* Autacoids
* Steroidal Drugs
* Drugs acting on the central nervous system

Diuretics; Cardiovascular drugs
* Thyroid and Anti thyroid drugs; Insulin and oral hypoglycemic agents
* Immunosuppressives and immunostimulants; Diagnostic agents; Pharmaceutical Aids; Microbial Transformations
* Enzyme Immobilization
* Different techniques of pharmaceutical analysis, Preliminaries and definitions
* Fundamentals of volumetric analysis
* Acid Base Titrations
* Oxidation Reduction Titrations
* Precipitation Titrations
* Gravimetric Analysis
* Non-aqueous titrations
* Complexometric titrations
* Miscellaneous Methods of Analysis
* Extraction procedures including separation of drugs from excipients; Potentiometry
* Conductometry
* Coulometry
* Polarography
* Amperometry
* Chromatography
* The Theoretical Aspects, Basic Instrumentation, Elements of Interpretation of Spectra, and Applications (quantitative and qualitative) of the Following Analytical Techniques
* Quality assurance

Pharmacology:-

Pathophysiology of common diseases; Basic Principles of Cell Injury and Adaptations
Basic Mechanisms involved in the process of inflammation and repair
Immunopathophysiology
Pathophysiology of Common Diseases
Fundamentals of general pharmacology
Pharmacology of Peripheral Nervous System
Pharmacology of Central Nervous System
Pharmacology of Cardiovascular System
Drugs Acting on the Hemopoietic System
Drugs acting on urinary system
Autacoids
Drugs Acting on the Respiratory System
Drugs acting on the Gastrointestinal Tract
Pharmacology of Endocrine System
Chemotherapy
Principles of Toxicology
Basic Concepts of Pharmacotherapy
Important Disorders of Organs, Systems and their Management
CNS Disorders
Depression Respiratory disease - Asthma.
Gastrointestinal Disorders - Peptic ulcer, Ulcerative colitis, Hepatitis, Cirrhosis.
Endocrine Disorders - Diabetes mellitus and Thyroid disorders.
Infectious Diseases - Tuberculosis, Urinary tract infections, Enteric infections, Upper respiratory infections. Hematopoietic Disorders- Anemias,Joint and Connective tissue disorders - Rheumatic diseases, Gout and Hyperuricemia.
Neoplastic Diseases - Acute Leukaemias, Hodgkin's disease. Therapeutic Drug Monitoring, Concept of Essential Drugs and Rational Drug use.


Pharmcognosy:-

* Sources of Drugs
* Biological, marine, mineral and plant tissue cultures as sources of drugs;
* Classification of Drugs
* Cultivation, Collection, Processing and Storage of Crude Drugs
* Quality Control of Crude Drugs
* Introduction to Active Constituents of Drugs
* Systematic pharmacognostic study of the followings:- CARBOHYDRATES and derived products, Lipids, RESINS, TANNINS, VOLATILE OILS, Phytochemical Screening, FIBERS
* GLYCOSIDE CONTAINING DRUGS:
* Saponins
* Cardioactive glycosides
* Anthraquinone cathartics:
* thers:- Psoralea, Ammi majus, Ammi visnaga, gentian, saffron, chirata, quassia.
* ALKALOID CONTAINING DRUGS:- Pyridine-piperidine, Tropane,
* Quinoline and Isoquinoline, Indole, Imidazole, Steroidal, Alkaloidal Amine, Glycoalkaloid, Purines, Studies of Traditional Drugs
General Techniques of Biosynthetic Studies and Basic Metabolic Pathways/Biogenesis
* Terpenes
* Carotenoids
* Glycosides
* Alkaloids
* Lignans, quassanoids and flavonoids. Role of plant-based drugs on National economy:
* Plant Tissue Culture
* Marine pharmacognosy